Original article
Breakthrough Covid-19 in Health Care WorkersM. Bergwerk and Others
Among 1497 health care workers who were fully vaccinated against Covid-19, 39 breakthrough infections were detected among those with full testing results between January 20 and April 28, 2021. The infected workers had mild symptoms or were asymptomatic and had lower titers of peri-infection neutralizing antibody than coworkers who were not infected
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JUL 28
Editorial
Looking Back and Looking ForwardE.J. Rubin, L.R. Baden, and S. Morrissey
In this audio interview conducted on July 27, the editors look at what we’ve learned, what we’ve endured, and how we can plan for the future.
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JUL 28
Original article
Tofacitinib for Covid-19 PneumoniaP.O. Guimarães and Others
Patients who were hospitalized with Covid-19 pneumonia were randomly assigned, at a median of 10 days after symptom onset, to receive tofacitinib or placebo. At 28 days, the risk of death or respiratory failure was lower in the tofacitinib group.
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JUL 29
INTERACTIVE MEDICAL CASE
A Periodic ProblemA. Kratka and Others
This interactive feature describes the case of a 27-year-old man who presented to the emergency department with weakness in both legs that was so severe he could not stand. Test your diagnostic and therapeutic skills.
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JUL 29
CLINICAL DECISIONS
Anticoagulation after Ablation for Atrial FibrillationS.R. Kadire, S.M. Al-Khatib, and H. Calkins
This interactive feature about management of atrial fibrillation offers a case vignette accompanied by two essays supporting different approaches to the use of anticoagulants after ablation for atrial fibrillation. Vote and comment.
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JUL 29
PERSPECTIVE
From Crime to CareN.P. Morris
Many clinicians are working on the front lines of decarceration, supporting and treating patients who might once have been incarcerated. Models for decarceration involving problem-solving courts and treatment are not perfect, but they allow physicians to do their part.
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JUL 29
PERSPECTIVE
Controversy and Progress in Alzheimer’s DiseaseG.D. Rabinovici
The FDA’s accelerated approval of aducanumab represents a landmark moment, though the drug’s road to the clinic has been rocky and contentious. The hope is that despite its limitations, this first-in-class drug will open the door to more efficacious therapies.
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JUL 29
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Image Challenge
What is the diagnosis?
An Icteric Tongue — A 12-year-old boy presented with a 4-day history of sore throat and a 3-day history of dark urine, abdominal pain, and pallor.
IMAGES IN CLINICAL MEDICINE
Acute Febrile Neutrophilic Dermatosis
A.M. Ayyash and R. Sampath
PERSPECTIVE
A Child’s Loss
D. Guyer
IMAGES IN CLINICAL MEDICINE
Malar Rash
S.E. Goglin and M.E. Margaretten